We study the regulation and evolution of gene expression using a combination of experimental and computational approaches. Our work brings together quantitative genetics, genomics, epigenetics, and evolutionary biology to achieve a deeper understanding of how genetic variation within and between species affects genome-wide gene expression and ultimately shapes the phenotypic diversity of life. Some of our long-term goals are to better understand: 1) How new mutations affect gene expression, 2) What selective pressures act on these mutations, 3) How (and how often) changes in gene expression affect other phenotypes, including human disease
Research lab has two main goals: to understand the regulation of entry into and progression through mitosis and meiosis, and to understand the basic logic of signaling cascades and loops.
My primary research interests are in computational biology, with an emphasis on spatial structure and dynamics at the molecular and cellular levels. My work, usually carried out in close collaboration with experimentalists, spans fields ranging from biochemistry and cell biology to parallel computing, image processing, and machine learning.
Experimental and computational approaches to study human movement. Development of biomechanical models to analyze muscleExperimental and computational approaches to study human movement. Development of biomechanical models to analyze muscle function, study movement abnormalities, design new medical products, and guide surgery. Imaging technology development including MRI and microendoscopy. Optogenetic manipulation of peripheral neural circuits. Biomedical technology development. function, study movement abnormalities, design new medical products, and guide surgery. Imaging technology development including MRI and microendoscopy. Optogenetic manipulation of peripheral neural circuits. Biomedical technology development.




