Snyder laboratory the first to perform a large-scale functional genomics project in any organism, and currently carries out a variety of projects in the areas of genomics and proteomics both in yeast and humans. These include the large-scale analysis of proteins using protein microarrays and the global mapping of the binding sites of chromosomal proteins. His laboratory built the first proteome chip for any organism and the first high resolution tiling array for the entire human genome.
Current projects are in developmental genomics (mouse), gene regulation and chromatin function (mouse and human), cancer genomics (human), and inherited rare disorders (human).
Research is on the mechanisms and consequences of HIV evolution with an emphasis on HIV drug resistance. Maintains an online database (HIV Drug Resistance Database ) designed to provide a publicly available resource for those performing HIV drug resistance surveillance, interpreting HIV drug resistance tests, and developing new antiretroviral drugs.
Dr. Shachter’s early work developed a method for purchasing an expert’s forecast that encourages accurate revelation of the expert’s beliefs as probabilities. His interest in medical decision analysis led to joint work on scheduling patients for follow-up bladder cancer therapy. In recent years, his research has focused on the representation, manipulation, and analysis of uncertainty and probabilistic reasoning in decision systems. As part of this work, he developed the DAVID influence diagram processing system for the Macintosh. He has worked closely with many students in Bioinformatics, where he holds a courtesy appointment.