Research lab has two main goals: to understand the regulation of entry into and progression through mitosis and meiosis, and to understand the basic logic of signaling cascades and loops.
My primary research interests are in computational biology, with an emphasis on spatial structure and dynamics at the molecular and cellular levels. My work, usually carried out in close collaboration with experimentalists, spans fields ranging from biochemistry and cell biology to parallel computing, image processing, and machine learning.
Experimental and computational approaches to study human movement. Development of biomechanical models to analyze muscleExperimental and computational approaches to study human movement. Development of biomechanical models to analyze muscle function, study movement abnormalities, design new medical products, and guide surgery. Imaging technology development including MRI and microendoscopy. Optogenetic manipulation of peripheral neural circuits. Biomedical technology development. function, study movement abnormalities, design new medical products, and guide surgery. Imaging technology development including MRI and microendoscopy. Optogenetic manipulation of peripheral neural circuits. Biomedical technology development.
The Das group strives to predict how sequence codes for structure in proteins, nucleic acids, and heteropolymers whose folds have yet to be explored. We use new computational and experimental tools to tackle the de novo modeling of protein and RNA folds, the high-throughput structure mapping of riboswitches and random RNAs, and the design of self-knotting and self-crystallizing nucleic acids.