November 15, 2024
11:00am – 12:00pm
Aaron M. Newman, PhD Associate Professor, CZ Biohub Investigator, Institute for Stem Cell Biology and Regenerative Medicine,
Dept. of Biomedical Data Science, Stanford University Decoding cellular plasticity and spatial
phenotypes in cancer Multicellular ecosystems are fundamental units of tissue organization and key elements of phenotypic variation. In cancer, such ecosystems – arising from immune, stromal, and/or malignant cells – form dynamic signaling hubs that
powerfully influence progression, immune evasion, and response to therapy. Moreover, within these hubs, cellular plasticity and stem cell regulatory programs play critical, yet poorly understood, roles in cancer pathogenesis. We have developed novel computational methods to resolve cell states and multicellular communities, tumor developmental hierarchies, and single-cell spatial relationships from genomic profiles of clinical biospecimens. In this talk, I will highlight these tools and illustrate how they can be applied across human
malignancies to address multiple biological and clinical questions of interest.
Friday, November 15, 2024
11:00 am -12:00 pm
Refreshments will be provided
Clark Center, S360, 3rd floor