Gina Bouchard: Computational frameworks to quantify and compare microenvironment spatial features of in vitro patient-derived models and clinical specimens are needed. Here, we acquired and analysed multiplexed immunofluorescence images of human lung adenocarcinoma (LUAD) alongside tumour-stroma assembloids constructed with organoids and fibroblasts harvested from the leading edge (Tumour-Adjacent Fibroblasts, TAFs) or core (Tumour Core Fibroblasts, TCFs) of human LUAD.
Read more: https://www.biorxiv.org/content/10.1101/2023.09.11.557278v1
