My laboratory is interested in aging and rejuvenation. To tackle the complexity of aging, we use high throughput approaches in model organisms with diverse lifespans – worms, killifish, and mice. We work to identify the genetics and epigenetic mechanisms underlying the aging clock and the pathways involved in modulating this aging clock in response to external stimuli, including diet. We are particularly excited to determine the mechanisms of brain aging and rejuvenation, focusing on the role of regenerative neural stem cells during aging. Finally, we have pioneered the short-lived African killifish as a new vertebrate model for aging and ‘suspended animation’ and are excited to use this scalable organismal model to uncover new genes and compounds that counter aging and age-related diseases.